Koebner Phenomenon in Psoriasis Is Not Associated with Deletion of Late Cornified Envelope Genes LCE3B and LCE3C

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A Replication Study of the Association between Rheumatoid Arthritis and Deletion of the Late Cornified Envelope Genes LCE3B and LCE3C

OBJECTIVE Two recent studies, in a Spanish and a Chinese population, point to an association between rheumatoid arthritis (RA) risk and the deletion of the Late Cornified Envelope (LCE) 3B and 3C genes (LCE3C_LCE3B-del), a known risk factor for psoriasis. We aimed to replicate these studies in a large Dutch cohort. METHODS 1039 RA cases and 759 controls were genotyped for LCE3C_LCE3B-del. Ass...

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Deletion of Late Cornified Envelope 3B and 3C genes is not associated with atopic dermatitis.

Atopic dermatitis (AD) and psoriasis are common skin diseases characterized by cutaneous inflammation and disturbed epidermal differentiation. Genome-wide analyses have shown overlapping susceptibility loci, such as the epidermal differentiation complex on chromosome 1q21. Recently, a deletion on 1q21 (LCE3C_LCE3B-del), comprising LCE3B and LCE3C, two members of the late cornified envelope (LCE...

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Deletion of LCE3C and LCE3B genes at PSORS4 does not contribute to susceptibility to psoriatic arthritis in German patients

INTRODUCTION Psoriasis susceptibility locus 4 (PSORS4) is a susceptibility locus for psoriasis vulgaris (PsV), a common inflammatory, hyperproliferative skin disorder. Recently, a deletion of 2 late cornified envelope (LCE) genes within epidermal differentiation complex on chromosome 1 was shown to be enriched in 1426 patients with PsV, suggesting compromised barrier function in deletion carrie...

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Psoriasis vulgaris is an inflammatory papulosquamous and koebner positive disease of the skin. The isotopic (koebner) response, a result of secondary dermatitis, is unrelated with former recovery of dermatitis. Although first reported by Wolf et. al (1) with a series of 58 patients, koebnerization resulting from Herpes Zoster infection is extremely rare in the current literature. A 74-year-old ...

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ژورنال

عنوان ژورنال: Journal of Investigative Dermatology

سال: 2012

ISSN: 0022-202X

DOI: 10.1038/jid.2011.336